The goal of the Pacific Innovations, Knowledge, and Opportunities (PIKO) Center is to build a statewide clinical and translational research (CTR) infrastructure to improve the health of IPP and the medically underserved and disadvantaged populations in Hawai‘i. To achieve this goal, PIKO seeks to fund, on a competitive basis, small grants to the faculty of Hawai‘i Pacific University (HPU), Chaminade University of Honolulu (CUH), and the University of Hawai‘i System for collaborative CTR research projects. The grant funding is intended to support promising pilot or preliminary research ideas that are likely to mature into larger federally-funded, independent research in the future. Pilot research teams will be led by new and/or early-stage investigators, or established investigators who are transitioning their programs of research to CTR (transitioning investigators). Under-represented minorities, particularly those of IPP descent, and individuals with disabilities are encouraged to apply.